業績

業績

2015年度/2014年度/2013年度/2012年度/2011年度

2015年度

  1. Inui N, Matsushima S, Kato S, Yasui H, Kono M, Fujisawa T, Enomoto N, Nakamura Y, Toyoshima M, Suda T: Effects of indacaterol versus tiotropium on respiratory mechanics assessed by the forced oscillation technique in patients with chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis,10:1139-1146, 2015.
  2. Hakamata A, Odagiri K, Miyakawa S, Irisawa H, Takeuchi K, Inui N, Tanaka S, Uchida S, Watanabe H: Pharmacokinetic and pharmacodynamic comparison of sildenafil-bosentan and sildenafil-ambrisentan combination therapies for pulmonary hypertension. Clin Transl Sci. 9(1):29-35, 2016.
  3. Wei J, Watanabe Y, Takeuchi K, Yamashita K, Tashiro M, Kita S, IwamotoT, Watanabe H, Kimura J: Nicorandil stimulates a Na+/Ca+ exchanger by activating guanylate cyclase in guinea pig cardiac myocytes. Pflugers Arch, 2015.
  4. Karayama M, Inui N, Fujisawa T, Enomoto N, Nakamura Y, Kuroishi S, Yokomura K, Koshimizu N, Sato M, Toyoshima M, Shirai T, Masuda M, Yamada T, Imokawa S, Suda T: Maintenance therapy with pemetrexed and bevacizumab versus pemetrexed monotherapy after induction therapy with carboplatin, pemetrexed, and bevacizumab in patients with advanced non-squamous non small cell lung cancer. Eur J Cancer. 58:30-37, 2016.
  5. Kusagaya H, Inui N, Karayama M, Fujisawa T, Enomoto N, Kuroishi S, Nakamura Y, Matsuda H, Yokomura K, Koshimizu N, Toyoshima M, Imokawa S, Yamada T, Shirai T, Hayakawa H, Suda T: Evaluation of palonosetron and dexamethasone with or without aprepitant to prevent carboplatin-induced nausea and vomiting in patients with advanced non-small-cell lung cancer. Lung Cancer. 90(3):410-6, 2015.
  6. Inoue Y, Inui N, Hashimoto D, Enomoto N, Fujisawa T, Nakamura Y, Suda T: Cumulative incidence and predictors of progression in corticosteroid-naïve Patients with sarcoidosis. PLoS One. 10(11):e0143371, 2015.
  7. Enomoto Y, Inui N, Imokawa S, Karayama M, Hasegawa H, Ozawa Y, Matsui T, Yokomura K, Suda T. Safety of topotecan monotherapy for relapsed small cell lung cancer patients with pre-existing interstitial lung disease. Cancer Chemother Pharmacol. 2015;76(3):499-505.
  8. Inoue Y, Inui N, Asada K, Karayama M, Matsuda H, Yokomura K, Koshimizu N, Imokawa S, Yamada T, Shirai T, Kasamatsu N, Suda T: Phase II study of erlotinib in elderly patients with non-small cell lung cancer harboring epidermal growth factor receptor mutations. Cancer Chemother Pharmacol. 76(1):155-61, 2015.
  9. Ikeda M, Enomoto N, Hashimoto D, Fujisawa T, Inui N, Nakamura Y, Suda T, Nagata T: Nontypeable Haemophilus influenzae exploits the interaction between protein-E and vitronectin for the adherence and invasion to bronchial epithelial cells. BMC Microbiol. 15(1):263, 2015.
  10. Inoue Y, Matsuura S, Kurabe N, Kahyo T, Mori H, Kawase A, Karayama M, Inui N, Funai K, Shinmura K, Suda T, Sugimura H: Clinicopathological and survival analysis of Japanese patients with resected non-small-cell lung cancer harboring NKX2-1, SETDB1, MET, HER2, SOX2, FGFR1, or PIK3CA gene amplification. J Thorac Oncol. 10(11):1590-600, 2015.
  11. Ozawa Y, Abe T, Omae M, Matsui T, Kato M, Hasegawa H, Enomoto Y, Ishihara T, Inui N, Yamada K, Yokomura K, Suda T: Impact of preexisting interstitial lung disease on acute, extensive radiation pneumonitis: retrospective analysis of patients with lung cancer. PLoS One. 10(10):e0140437, 2015.
  12. Mori K, Fujisawa T, Kusagaya H, Yamanaka K, Hashimoto D, Enomoto N, Inui N, Nakamura Y, Maekawa M, Suda T: Synergistic proinflammatory responses by IL-17A and toll-like receptor 3 in human airway epithelial cells. PLoS One. 29;10(9):e0139491, 2015.
  13. Ozawa Y, Omae M, Fujii M, Matsui T, Kato M, Sagisaka S, Asada K, Karayama M, Shirai T, Yasuda K, Nakamura Y, Inui N, Yamada K, Yokomura K, Suda T: Management of brain metastasis with magnetic resonance imaging and stereotactic irradiation attenuated benefits of prophylactic cranial irradiation in patients with limited-stage small cell lung cancer. BMC Cancer. 15:589, 2015.
  14. Hasunuma T, Tohkin M, Kaniwa N, Jang lJ, Yimin C, Kaneko M, Saito Y, Takeuchi M, Watanabe H, Yamazoe Y, Uyama Y, Kawai S: Absence of ethnic difference in the phamacokinetics of moxifloxacin, simvastatin and meloxicam among three East Asian population and Caucasians.Br. J. Clin Pharmacol, doi: 0.1111/cts.12384, 2016.
  15. 古家英寿, 本村琢哉, 笹川高広, 中村明生, 渡邉裕司: NS-24(トラマドール塩酸塩徐放錠)の臨床第Ⅰ相試験-健康成人男性における単回および反復投与試験、食事の影響試験、即放性製剤との比較試験-. 臨床医薬, 31(5):431-451, 2015.
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2014年度

  1. Odagiri K, Mizuta I, Yamamoto M, Miyazaki Y, Watanabe H, Uehara A: Waist to Height Ratio is an Independent Predictor for the Incidence of Chronic Kidney Disease. PLOS ONE, 9(2):e88873, 2014.
  2. Wei J, Zhang J, Si Y, Kanada M, Zhang Z, Terakawa S, Watanabe H: Blockage of LMP1-modulated store-operated Ca2+ entry reduces metastatic potential in nasopharyngeal carcinoma cell. Cancer Lett, 360(2):234-244, 2015.
  3. Furuta T, Sugimoto M, Yamade M, Uotani T, Sahara S, Ichikawa H, Kagami T, Yamada T, Osawa S, Sugimoto K, Watanabe H, Umemura K: Eradication of H. pylori infection in patients to penicillin using tripe therapy with a PPI, metronidazole and sitafloxacin. Intern Med, 53(6): 571-575, 2014.
  4. Uotani T, Sugimoto M, Nishino M, Ichikawa H, Sahara S, Yamade M, Iwaizumi M, Yamada T, Osawa S, Sugimoto K, Umemura K, Watanabe H, Miyajima H, Furuta T: Prevention of gastric mucosal injury induced by anti-platelet drugs by famotidine. J Clin Pharmacol, 54(8):858-864, 2014.
  5. Tanaka S, Uchida S, Inui N, Takeuchi K, Watanabe H, Namiki N: Simultaneous LC-MS/MS Analysis of the Plasma Concentrations of a Cocktail of 5 Cytochrome P450 Substrate Drugs and Their Metabolites. Biol Pharm Bull, 37(1):18-25, 2014.
  6. Kurihara C, Kusuoka H, Ono S, Kakee N, Saito K, Takehara K, Tsujiide K, Nabeoka Y, Sakuhiro T, Aoki H, Morishita N, Suzuki C, Kachi S, Kondo E, Komori Y, Isobe T, Kageyama S, Watanabe H: High Rate of Awarding Compensation for Claims of Injuries Related to Clinical Trials by Pharmaceutical Companies in Japan: A Questionnaire Survey. PLOS ONE, 9(1):e84998, 2014.
  7. Kashiwagura Y, Uchida S, Tanaka S, Watanabe H, Masuzawa M, Sasaki T, Namiki N: Clinical efficacy and pharmacokinetics of levothyroxine suppository in patients with hypothyroidism. Biol Pharm Bull, 37(4): 666-670, 2014.
  8. Misaka S, Yatabe J, Muller F, Takano K, Kawabe K, Glaeser H, Yatabe MS, Onoue S, Werba JP, Watanabe H, Yamada S, Fromm MF, Kimura J: Green tea ingestion greatly reduces plasma concentrations of nadolol in healthy subjects. Clin Pharmacol Ther, 95(4): 432-438, 2014.
  9. Imai H, Watanabe M, Fujita T, Watanabe H, Harada K, Moritoyo T, Goto K, Kotegawa T, Ohashi K, Uchida E, Ikeda Y, Suzuki T, Hasunuma T, Okumura T, Kumagai Y, Takeuchi K, Inui N, Furuta T, Urano T, Mogami H, Iwaki T, Miyashima N, Okura T, Miyoshi K, Kurata M, Irita J, Enomoto D, Matsuura B, Furukawa S, Ueda A, Miyake T, Nagai M, Moritoyo H, Shimizu H, Koizumi M, Nomoto M: ANTCliPh (Academic Network for Trials in Clinical Pharmacology) Trial 04 Study Group. Pharmacokinetics of teriparatide after subcutaneous administration to volunteers with renal failure. Int J Clin Pharmacol Ther, 52(2):166-174, 2014.
  10. Ohmae E, Nishio S, Oda M, Suzuki H, Suzuki T, Ohashi K, Koga S, Yamashita Y, Watanabe H: Sensitivity correction for the influence of the fat layer on muscle oxygenation and estimation of fat thickness by time-resolved spectroscopy, J Biomed opt, 19(6):e067005, 2014.
  11. Sato R, Maekawa M, Genma R, Shirai K, Ohki S, Morita H, Suda T, Watanabe H: Final Height and Cardiometabolic Outcomes in Young Adults with Very Low Birth Weight(<1500g). PLOS ONE, 9(11):e112286, 2014.
  12. Hayashi T, Kubota K, Kawashima S, Sone H, Watanabe H, Ohrui T, Yokote K, Takemoto M, Araki A, Noda M, Noto H, Sakuma I, Yoshizumi M, Ina K, Nomura H: Efficacy of HMG-CoA reductase inhibitors in the Prevention of cerebrovascular attack in 1016 patients older than 75 years among 4014 type 2 diabetic individuals. Int J Cardiol, 177(3):860-866, 2014.
  13. Werba JP, Misaka S, Giroli MG, Yamada S, Cavalca V, Kawabe K, Squellerio L, LaguzziF, Onoue S, Veglia F, Myasoedova V, Takeuchi K, Adachi E, Tremoli E, Watanabe H: Overview of Green Tea interaction with Cardiovascular Drugs. Curr Pharm Des, 21(9): 1213-1219, 2015.
  14. Sato R, Ikuma M, Takagi K, Yamagishi Y, Asano J, Matsunaga Y, Watanabe H: Exposure of drugs for hypertension, diabetes, and autoimmune disease during pregnancy and perinatal outcomes: an investigation of the regulator in Japan. Medicine (Baltimore), 94(1):e386, 2015.
  15. Ito Y, Karayama M, Inui N, Kuroishi S, Nakano H, Nakamura Y, Yokomura K, Toyoshima M, Shirai T, Masuda M, Yamada T, Yasuda K, Hayakawa H, Suda T, Chida K: Aprepitant in patients with advanced non-small-cell lung cancer receiving carboplatin-based chemotherapy. Lung Cancer, 84(3):259-264, 2014.
  16. Kato M, Fujisawa T, Hashimoto D, Kono M, Enomoto N, Nakamura Y, Inui N, Hamada E, Miyazaki O, Kurashita S, Maekawa M, Suda T: Plasma connective tissue growth factor levels as potential biomarkers of airway obstruction in patients with asthma. Ann Allergy Asthma Immunol, 113(3):295-300, 2014.
  17. Fujisawa T, Hozumi H, Kono M, Enomoto N, Hashimoto D, Nakamura Y, Inui N, Yokomura K, Koshimizu N, Toyoshima M, Shirai T, Yasuda K, Hayakawa H, Suda T: Prognostic factors for myositis-associated interstitial lung disease. PLOS ONE, 9(6):e98824, 2014.
  18. Enomoto N, Kusagaya H, Oyama Y, Kono M, Kaida Y, Kuroishi S, Hashimoto D, Fujisawa T, Yokomura K, Inui N, Nakamura Y, Suda T: Quantitative analysis of lung elastic fibers in idiopathic pleuroparenchymal fibroelastosis (IPPFE): comparison of clinical, radiological, and pathological findings with those of idiopathic pulmonary fibrosis (IPF). BMC Pulm Med, 14:91, 2014.
  19. Kono M, Nakamura Y, Enomoto N, Hashimoto D, Fujisawa T, Inui N, Maekawa M, Suda T, Colby TV, Chida K: Usual interstitial pneumonia preceding collagen vascular disease: a retrospective case control study of patients initially diagnosed with idiopathic pulmonary fibrosis. PLOS ONE, 15;9(4):e94775, 2014.
  20. Akamatsu T, Shirai T, Kato M, Yasui H, Hashimoto D, Fujisawa T, Tsuchiya T, Inui N, Suda T, Chida K: Switching from salmeterol/fluticasone to formoterol/budesonide combinations improves peripheral airway/alveolar inflammation in asthma. Pulm Pharmacol Ther, 27:52-56, 2014.
  21. Miwa S, Shirai M, Toyoshima M, Shirai T, Yasuda K, Yokomura K, Yamada T, Masuda M, Inui N, Chida K, Suda T, Hayakawa H: Efficacy of clarithromycin and ethambutol for Mycobacterium avium complex pulmonary disease. A preliminary study. Ann Am Thorac Soc, 11:23-29, 2014.
  22. Akamatsu T, Inui N, Kusagaya H, Nakamura Y, Suda T, Chida K: Evaluation of antibody levels over 3 years after 23-valent pneumococcal polysaccharide vaccination in patients with pulmonary diseases receiving steroids and immunosuppressive agents. Clin Biochem, 48(3):125-129, 2015.
  23. Matsushima S, Inui N, Yasui H, Kono M, Nakamura Y, Toyoshima M, Shirai T, Suda T: Indacaterol and tiotropium combination therapy in patients with chronic obstructive pulmonary disease. Pulm Pharmacol Ther, 30:11-15, 2015.
  24. Enomoto N, Mikamo M, Oyama Y, Kono M, Hashimoto D, Fujisawa T, Inui N, Nakamura Y, Yasuda H, Kato A, Mimuro S, Doi M, Sato S, Suda T: Treatment of acute exacerbation of idiopathic pulmonary fibrosis with direct hemoperfusion using a polymyxin B-immobilized fiber column improves survival. BMC Pulm Med, 15(1):15, 2015.
  25. Hozumi H, Enomoto N, Kono M, Fujisawa T, Inui N, Nakamura Y, Sumikawa H, Johkoh T, Nakashima R, Imura Y, Mimori T, Suda T: Prognostic Significance of Anti-Aminoacyl-tRNA Synthetase Antibodies in Polymyositis/Dermatomyositis-Associated Interstitial Lung Disease: A Retrospective Case Control Study. PLOS ONE, 10(3):e0120313, 2015.
  26. Oyama Y, Fujisawa T, Hashimoto D, Enomoto N, Nakamura Y, Inui N, Kuroishi S, Yokomura K, Toyoshima M, Yamada T, Shirai T, Masuda M, Yasuda K, Hayakawa H, Chida K, Suda T: Efficacy of short-term prednisolone treatment in patients with chronic eosinophilic pneumonia. Eur Respir J, 2015.
  27. 花田隆造, 渡邉裕司: エボラ出血熱に対する医薬品候補物のコンパッショネート使用について. 臨床薬理, 45(6):263-267, 2014.
  28. 影山 淳, 小田切圭一, 鈴木直子, 本田久美子, 尾上和永, 山本誠, 水田潔, 上原明彦: 職域における集団健康教育の教育効果および行動変容につながる教育方法の検討. 産業衛生学会誌, 56(5):141-151, 2014.
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2013年度

  1. Inui N, Akamatsu T, Uchida S, Tanaka S, Namiki N, Karayama M, Chida K, Watanabe H: Chronological Effects of Rifampicin Discontinuation on Cytochrome P450 Activity in Healthy Japanese Volunteers, Using the Cocktail Method. Clin Pharmacol Ther 94(6):702-708, 2013.
  2. Wei J, Takeuchi K, Watanabe H: Linoleic Acid Attenuates Endothelium-derived Relaxing Factor Production by Suppressing cAMP-hydrolyzing Phosphodiesterase Activity. Circulation Journal 77(11):2823-2830, 2013.
  3. Misaka S, Kawabe K, Onoue S, Werba JP, Giroli M, Tamaki S, Kan T, Kimura J, Watanabe H, Yamada S: Effects of green tea catechins on cytochrome P450 2B6,2C8,2C19,2D6 and 3A activities in human liver and intestinal microsomes. Drug Metabolism&Pharmacokinetics 28(3):244-249, 2013.
  4. Irisawa H, Takeuchi K, Inui N, Miyakawa S, Morishima Y, Mizushima T, Watanabe H: Incremental shuttle walk test as a valuable assessment of exercise performance in patients with pulmonary arterial hypertension. Circulation Journal 78(1):215-221, 2013.
  5. Miyakawa S, Odagiri K, Inui N, Hakamata A, Goto T, Tanaka S, Uchida U, Namiki N, Watanabe H: Short-Term Drug-Drug Interaction between Sildenafil and Bosentan under Long-Term Use in Patients with Pulmonary Arterial Hypertension. Pharmacology & Pharmacy 4(7):542-548, 2013.
  6. Misaka S, Kawabe K, Onoue S, Werba JP, Giroli M, Kimura J, Watanabe H, Yamada S: Development of rapid and simultaneous quantitative method for green tea catechins on the bioanalytical study using UPLC/ESI-MS. Biomed Chromatogr 27(1):1-6, 2013.
  7. Misaka S, Kawabe K, Onoue S, Werba JP, Giroli M, Watanabe H, Yamada S: Green tea extract affects cytochrome P450 3A activity and phamacokinetics of simvastatin in rats. Drug Metabolism& Pharmacokinetics 28(6):514-518, 2013
  8. Tanaka S, Uchida S, Miyakawa S, Inui N, Takeuchi K, Watanabe H, Namiki N: Comparison of Inhibitory Duration of Grapefruit Juice on Organic Anion-Transporting Polypeptide and Cytochrome P450 3A4. Biol Pharm Bull 36(12):1936-1941, 2013
  9. Fukumoto Y, Yamada N, Matsubara H, Mizoguchi M, Uchino K, Yao A, Kihara Y, Kawano M, Watanabe H, Takeda Y, Adachi T, Osanai S, Tanabe N, Inoue T, Nakano T, Shimokawa H: Double-blind, Placebo-controlled Clinical Trial with a Rho-kinase Inhibitor in Pulmonary Arterial Hypertension; A Pilot Efficacy Trial. Circulation Journal 77(10):2619-2625, 2013.
  10. Kuwana M, Watanabe H, Matsuoka N, Sugiyama N: Pulmonary arterial hypertension associated with connective tissue disease: meta-analysis of clinical trials. BMJ Open 13;3(8):e003113, 2013.
  11. Karayama M, Inui N, Kuroishi S, Yokomura K, Toyoshima M, Shirai T, Masuda M, Yamada T, Yasuda K, Suda T, Chida K: Maintenance therapy with pemetrexed versus docetaxel after induction therapy with carboplatin and pemetrexed in chemotherapy-naive patients with advanced non-squamous non-small-cell lung cancer: a randomized, phase II study. Cancer Chemother Pharmacol 72:445-452, 2013.
  12. Yasui H, MD; Inui N, Furuhashi, K, Uto T, Nakamura Y, Sato J, Yasuda K, Takehara Y, Suda T, Chida K: Multidetector-row computed tomography assessment of adding budesonide/formoterol to tiotropium in patients with chronic obstructive pulmonary disease. Pulm Pharmacol Ther 26:336-341, 2013
  13. Harada M, Inui N, Suda T, Nakamura Y, Wajima T, Matsuo Y, Chida K: Pharmacokinetic analysis of doripenem in elderly patients with nosocomial pneumonia. Int J Antimicrob Agents 42:149-154, 2013.
  14. Hozumi H, Tsujimura K, Yamamura Y, Seto S, Uchijima M, Nagata T, Miwa S, Hayakawa H, Fujisawa T, Hashimoto D, Inui N, Suda T, Chida K, Koide Y: Immunogenicity of dormancy-related antigens in individuals infected with Mycobacterium tuberculosis in Japan. Int J Tuberc Lung Dis 17:818-824, 2013.
  15. Matsuura S, Kahyo T, Shinmura K, Iwaizumi M, Yamada H, Funai K, Kobayashi J, Tanahashi M, Niwa H, Ogawa H, Takahashi T, Inui N, Suda T, Chida K, Watanabe Y, Sugimura H: SGOL1 variant Binduces abnormal mitosis and resistance to taxane in non-small cell lung cancers. Sci Rep 22:3012, 2013.
  16. Suzuki Y, Miwa S, Akamatsu T, Suzuki M, Fujie M, Nakamura Y, Inui N, Hayakawa H, Chida K, Suda T: Indoleamine 2,3-dioxygenase in the pathogenesis of tuberculous pleurisy. Int J Tuberc Lung Dis 17:1501-1506, 2013.
  17. Hozumi H, Nakamura Y, Johkoh T, Sumikawa H, Colby TV, Kono M, Hashimoto D, Enomoto N, Fujisawa T, Inui N, Suda T, Chida K: Acute exacerbation in rheumatoid arthritis-associated interstitial lung disease: a retrospective case control study. BMJ Open 13;3(9):e003132, 2013
  18. Enomoto N, Suda T, Kono M, Kaida Y, Hashimoto D, Fujisawa T, Inui N, Nakamura Y, Imokawa S, Funai K, Chida K: Amount of elastic fibers predicts prognosis of idiopathic pulmonary fibrosis. Respir Med 107:1608-1616, 2013.
  19. Kusagaya H, Fujisawa T, Yamanaka K, Mori K, Hashimoto D, Enomoto N, Inui N, Nakamura Y, Wu R, Maekawa M, Suda T, Chida K: Toll-like receptor-mediated airway IL-17C enhances epithelial host defense in an autocrine/paracrine manner. Am J Respir Cell Mol Biol 50:30-39, 2013.
  20. Fujisawa T, Yasui H, Akamatsu T, Hashimoto D, Enomoto N, Inui N, Nakamura Y, Maekawa M, Suda T, Chida K: Alveolar nitric oxide concentration reflects peripheral airway obstruction in stable asthma. Respirology 18:522-527, 2013.
  21. Akamatsu T, Shirai T, Kato M, Yasui H, Hashimoto D, Fujisawa T, Tsuchiya T, Inui N, Suda T, Chida K: Switching from salmeterol/fluticasone to formoterol/budesonide combinations improves peripheral airway/alveolar inflammation in asthma. Pulm Pharmacol Ther 27:52-56, 2013.
  22. Furuta T, Soya Y, Sugimoto M, Nishino M, Yamade M, Uotani T, Kodaira C, Sahara S, Ichikawa H, Yamada T, Osawa S, Sugimoto K, Maekawa M, Watanabe H, Umemura K: Rapid Automated Genotyping of CYP2C19 and Helicobacter pylori 23S rRNA Gene in Gastric Juice. Journal of Gastroenterology and Hepatology Research 2(4):508-512, 2013
  23. Zhang J, Wei J, Kanada M, Yan L, Zhang Z, Watanabe H, Terakawa S: Inhibition of store-operated Ca2+ entry suppresses EGF-induced migration and eliminates extravasation from vasculature in nasopharyngeal carcinoma cell. Cancer Letters 336(2):390-7, 2013.
  24. Sugimoto M, Uotani T, Nishino M, Yamade M, Sahara S, Yamada T, Osawa S, Sugimoto K, Umemura K, Watanabe H, Miyajima H, Furuta T: Antiplatelet Drugs Are a Risk Factor for Esophageal Mucosal Injury. Digestion 87(4):281-289, 2013
  25. Furuta T, Sugimoto M, Kodaira C, Nishino M, Yamade M, Uotani T, Sahara S, Ichikawa H, Yamada T, Osawa S, Sugimoto K, Watanabe H, Umemura K: Sitafloxacin-based third-line rescue regimens for Helicobacter pylori infection in Japan. J Gastroenterol Hepatol 29(3):487-93, 2014.
  26. Furuta T, Sugimoto M, Yamade M, Uotani T, Sahara S, Ichikawa H, Yamada T, Osawa S, Sugimoto K, Watanabe H, Umemura K: Effect of dosing schemes of amoxicillin on eradication rates of Helicobacter pylori with amoxicillin-based triple therapy. J Clin Pharmacol 54(3):258-66, 2014.
  27. Nishino M, Sugimoto M, Uotani T, Yamade M, Sahara S, Ichikawa H, Sugimoto K, Umemura K, Watanabe H, Miyajima H, Furuta T: Association of gastric mucosal injury severity with platelet function and gastric pH during low-dose aspirin treatment. Digestion 88(2):79-86, 2013.
  28. 山口光峰、近藤充弘、山本学、星順子、清水亜紀、近藤恵美子、大澤智子、田島康則、高崎可奈子、中村悟、城谷真理、宇井英明、瀬戸宏格、青木孝仁、藤岡慶壮、若井修治、渡邉裕司、楠岡英雄:治験関連文書における電磁的記録の活用について.臨床評価 41(1):209-240, 2013
  29. 内田信也、渡邉裕司、並木徳之:薬物相互作用の検出を目的としたラットおよび人を対象としたカクテル試験 代謝酵素およびトランスポーターを介する薬物相互作用の解析.臨床薬理の進歩 34:17-25, 2013
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2012年度

  1. Sato R, Watanabe H, Genma R, Takeuchi M, Maekawa M, Nakamura H: Future perspective on pharmacogenomics of severe hypoglycemia associated with sulfonylureas. Pharmacogenomics, 13:9-10,2012.
  2. Sato R, Watanabe H, Shirai K, Ohki S, Genma R, Morita H, Inoue E, Takeuchi M, Maekawa M, Nakamura H: A cross-sectional study of glucose regulation in young adults with very low birth weight: impact of male gender on hyperglycaemia. BMJ Open, 2:e000327, 2012.
  3. Inui N, Hasegawa H, Suda T, Nakamura Y, Watanabe H, Chida K: Expression and function of drug resistance protein 1 and multidrug resistance-associated protein 1 in lung dendritic cells from aging mice. J Gerontol A Biol Sci Med Sci, 67: 1049- 1055, 2012.
  4. Inui N, Kato T, Uchida S, Chida K, Takeuchi K, Kimura T, Watanabe H: Novel patch for transdermal administration of morphine. J Pain Symptom Management, 44: 479-485,2012
  5. Kotegawa T, Tsutsumi K, Morita H, Imai H, Morita M, Yoshizato T, Ohyama T, Uchida S, Watanabe H, Namiki N, Ohashi K.: Effects of dosing interval on the pharmacokinetic and pharmacodynamic interactions between the oral adsorbent AST-120 and triazolam in humans. Eur J Clin Pharmacol, 68: 1605-1610, 2012.
  6. Uotani T, Sugimoto M, Nishino M, Kodaira C,Yamade M, Sahara S, Yamada T, Osawa S, Sugimoto K, Tanaka T, Umemura K, Watanabe H, Miyajima H, Furuta T: Ability of rabeprazole to prevent gastric mucosal damage from clopidogrel and low doses of aspirin depends on CYP2C19 genotype. Clin Gastroenterol Hepatol, 10:879-885,2012.
  7. Yamakawa T, Watanabe Y, Watanabe H, Kimura J: Inhibitory effect of cibenzoline on na(+)/ca(2+) exchange current in Guinea-pig cardiac ventricular myocytes. J Pharmacol Sci., 120: 59-62, 2012.
  8. Yasui H, Fujisawa T, Inui N, Kato M, Hashimoto D, Enomoto N, Nakamura Y, Shirai T, Suda T, Nakamura H, Chida K: Impact of add-on pranlukast in stable asthma;the additive effect on peripheral airway inflammation. Respir Med .106:508-514,2012.
  9. Suzuki Y, Suda T, Asada K, Miwa S, Suzuki M, Fujie M, Furubashi K, Nakamura Y Inui N, Hayakawa H, Nakamura H, Chida K: Serum indoleamine 2,3-dioxygenase activity predicts prognosis of pulmonary tuberculosis. Clin Vaccine Immunol, 19: 436-442, 2012.
  10. Suzuki Y, Suda T, Furuhashi K, Shibata K, Hashimoto D, Enomoto N, Fujisawa T, Nakamura Y, Inui N, Nakamura H, Chida K: Mouse CDllb high lung dendritic cells have more potent capability to induce lgA than CD103* lung dendritic cells in vitro. Am J Respir Cell Mol Biol, 46:773-780, 2012.
  11. Akamatsu T, Shirai T, Kato M , Hashimoto D, Yasui H, Inui N, Suda T, Yokomura K, Hayakawa H, Ide K, Toyoshima M, Kuroishi S ,Yasuda K, Suganuma H, Yamada T, Masuda M ,Chida K: Effect of switching from almetero1/fluticasone to formoterol/budesonide combination in patients with uncontrolled asthma. Allergol Int, 61: 323-329, 2012.
  12. Kusagaya H, Inui N, Karayama M, Nakamura Y, Kuroishi S, Yokomura K, Toyoshima M, Shirai T, Masuda M, Yamada61: 323uda K, Suda T, Chida K: Biweekly combination therapy with gemcitabine and carboplatin compared with gemcitabine monotherapy in elderly patients with advanced non-small-cell lung cancer: A randomized, phase-II study. Lung Cancer, 77: 550-555, 2012.
  13. Nakamura Y, Suda T, Kaida Y, Kono M, Hozumi H, Hashimoto D, Enomoto N, Fujisawa T, Inui N, Imokawa S, Yasuda K, Shirai T, Suganuma H, Morita S, Hayakawa H, Takehara Y, Colby TV, Chida K: Rheumatoid lung disease: prognostic analysis of 54 biopsy-proven cases. Respir Med, 106: 1164-1169,2012.
  14. Karayama M, Inui N, Suda T, Nakamura Y, Enomoto N, Chida K.: Pulmonary dendritic cell accumulation in usual interstitial pneumonia and nonspecific interstitial pneumonia. Sarcoidosis Vasc Diffuse Lung Dis, 29:69-73,2012.
  15. Furuhashi K, Suda T, Hasegawa H, Suzuki Y, Hashimoto D, Enomoto N, Fujisawa T, Nakamura Y, Inui N, Shibata K, Nakamura H, Chida K: Mouse lung CD103+ and CD11b high dendritic cells preferentially induce distinct CD4+T cell responses. Am J Respir Cell Mol Biol, 46:773-780,2012.
  16. Suzuki Y, Suda T, Asada K, Miwa S, Suzuki M, Fujie M, Furuhashi K, Nakamura Y, Inui N, Hayakawa H, Nakamura H, Chida K: Serum indoleamine 2,3-dioxygenase activity predicts prognosis of pulmonary tuberculosis. Clin Vaccine Immunol, 19: 436- 442,2012.
  17. Yasui H, Fujisawa T, Inui N, Kato M, Hashimoto D, Enomoto N, Nakamura Y, Shirai T, Suda T, Nakamura H, Chida K: Impact of add-on pranlukast in stable asthma;the additive effect on peripheral airway inflammation. Respir Med.106: 508-514,2012.
  18. 渡邉裕司, 景山茂, 楠岡英雄, 藤原康弘, 小野俊介, 斉藤和幸, 中村秀文, 山本晴子, 笠井宏委, 川島弓枝, 米盛勧, 山本学,栗原千絵子, 中島唯善, 青木寛, 可知茂男, 鈴木千恵子, 中山智紀, 近藤恵美子, 星順子: 治験と臨床研究の新しい潮流 国内動向 医師主導治験の現状と課題.臨床評価,40:5-18,2012.
  19. 渡邉裕司,景山茂,楠岡英雄,藤原康弘,小野俊介,斉藤和幸,中村秀文,山本晴子,笠井宏委,川島弓枝,米盛勧,山本学,栗原千絵子,中島唯善,青木寛,可知茂男,鈴木千恵子,中山智紀,近藤恵美子,星順子: 医師主導治験の現状と課題. 臨床評価,40(1):5-18, 2012.
  20. 渡邉裕司: 創薬/創医療機器 なぜ私は海外に活路を求めるのか、なぜ私は日本に活路を見いだすのか 医薬品開発 日本での活路を見出すために. 臨床医薬,28(8):713-726,2012.
  21. 乾直輝, 渡邉裕司: リファンピシンによる薬物代謝酵素チトクロームP450誘導作用のカクテル法を用いた経時的検討.臨床薬理の進歩,33:1-8, 2012.
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2011年度

  1. Misaka S, Nakamura R, Uchida S, Takeuchi K, Takahashi N, Inui N, Kosuge K, Yamada S, Watanabe H: Effect of 2 weeks' consumption of pomegranate juice on the pharmacokinetics of a single dose of midazolam: an open-label, randomized, single-center, 2-period crossover study in healthy Japanese volunteers. Clin Ther, 33:246-252,2011.
  2. Satoh T, Saji T, Watanabe H, Ogawa S, Takehara K, Tanabe N, Yamada N, Yao A, Miyaji K, Nakanishi N, Suzuki Y, Fujiwara T, Kuriyama T : A PhaseⅢ, Multicenter, Collaborative, Open-Label Clinical Trial of Sildenafil in Japanese Patients With Pulmonary Arterial Hypertension. Circulation Journal,75:677-682,2011.
  3. Takeuchi K, Watanabe H: Pulmonary Arterial Hypertension Associated With Connective Tissue Disease and Immunosuppressive Therapy. Circulation Journal, 75 : 2543-2544,2011
  4. Hasegawa H, Inui N, Suda T, Shibata K, Nakamura Y, Watanabe H, Nakamura H, Chida K: Expressions of multidrug resistance protein 1 and multidrug resistance -associated protein 1 in lung dendritic cells. Life Sci, 89:282-287,2011.
  5. Kodaira C, Uchida S, Yamade M, Nishino M, Ikuma M, Namiki N, Sugimoto M, Watanabe H, Hishida A, Furuta T:Influence of different proton pump inhibitors on activity of cytochrome P450 assessed by [(13)C]-aminopyrine breath test. J Clin Pharmacol, 52:432-439,2011.
  6. Misaka S, Nakamura R, Uchida S, Takeuchi K, Takahashi N, Inui N, Kosuge K, Yamada S, Watanabe H: Effects of 2 weeks` consumption of pomegranate juice on the pharmacokinetics of a single dose of midazolam: an open-label. randomized single- center, 2-period crossover study in healthy Japanese volunteers. Clin Ther, 33: 246- 252,2011.
  7. Hayashi T, Kawashima S, Nomura H, Itoh H, Yamada N, Sone H, Watanabe H, Ohrui T, Yokote K, Sone H, Hattori Y, Yoshizumi M, Ina K, Kubota K: Age, gender, nsulin and blood glucose control status alter the risk of ischemic heart disease and stroke among elderly diabetic patients. Cardiovascular Diabetology, 10: 2011.
  8. Matsuura S, Inui N, Ozawa Y, Nakamura Y, Toyoshima M, Yasuda K, Yamada T, Shirai T, Suganuma H, Yokomura K, Suda T, Chida K: PhaseⅡ study of erlotinib as third-line Monotherapy in patients with advanced non-small-cell lung cancer without epidermal growth factor receptor mutations. Jpn J Clin Oncol, 41:959-963,2011.
  9. Furuhashi K, Suda T, Hasegawa H, Suzuki Y, Hashimoto D, Enomoto N, Fujisawa T, Nakamura Y, Inui N, Shibata K, Nakamura H, Chida K : Mouse lung CD103+ and CD11b high dendritic cells preferentially induce distinct CD4+T cell responses. Am J Respir cell Mol Biol, 46:165-172,2011.
  10. Kato M, Nakamura Y, Suda T, Ozawa Y, Inui N, Seo N, Nagata T, Koide Y, Kalinski P, Nakamura H, Chida K: Enhanced anti-tumor immunity by superantigen-pulsed dendritic cells. Cancer Immunol Immunother, 60:1029-1038,2011.
  11. Suzuki Y, Suda T, Yokomura K, Suzuki M, Fujie M , Furuhashi K, Hashimoto D, Enomoto N , Fujisawa T, Nakamura Y, Inui N, Nakano Y, Nakamura H, Chida K: Serum activity of indoleamine2,3-dioxygenase predicts prognosis of community- acquired pneumonia. J Infect, 63:215-222,2011.
  12. Kono M, Nakamura Y, Suda T, Kato M, Kaida Y, Hashimoto D, Inui N, Hamada E, Miyazaki O, Kurasita S, Fukamachi I, Endo K, Ng PS, Takehara K, Nakamura H, Maekawa M, Chida K: Plasma CCN2(connective tissue growth factor;CTGF)is a potential biomarker in idiopathic pulmonary fibrosis(IPF).Clinical Chimica Acta, 412:2211-2215,2011.
  13. Kono M, Suda T, Enomoto N, Nakamura Y, Kaida Y, Hashimoto D, Inui N, Mizuguchi T, Kato A, Shirai T, Nakamura H, Chida K: Evaluation of different perfusion durations in direct hemoperfusion with polymyxin B-immobilized fiber colum therapy for acute exacerbation of interstitial pneumonias. Blood Purif, 32:75-81,2011.
  14. Hozumi H, Nakamura Y, Johkoh T , Sumikawa H, Colby TV, Karayama M , Hayakawa H, Yokomura K, Imokawa S, Yasuda K, Toyoshima M , Suganuma H, Shirai T, Inui N, Suda T, Nakamura H, Chida K: Nonspecific interstitial pneumonia: Prognostic significance of high-resolution computed tomography in 59patients. J Comput Assist Tomogr, 35:583-589,2011.
  15. 渡邉裕司,景山茂,楠岡英雄,小野俊介,斉藤和幸,磯部哲,掛江直子,栗原千絵子,作広卓哉,青木寛,辻出清和,鍋岡勇造,森下典子,鈴木千恵子,可知茂男,竹原健二,辻本好子,近藤恵美子,小森有希子: 治験に係る健康被害発生時の被験者保護と補償-実態調査を踏まえた情報提供のあり方の提言-.臨床評価,39:5-29,2011.
  16. 梅村和夫,古田隆久,杉本光繁,岩城孝行,渡邉裕司,竹内和彦,乾直輝,浦野哲盟,鈴木優子,小林康孝,竹内譲,三浦豊章,横山広美,折坂早苗,村松倫子,岸谷融,大西明弘: ドネジベル塩酸塩OD錠5mg「サワイ」の健康成人における生物学的同等性試験.診療と新薬, 48:871-879, 2011.
  17. 梅村和夫,古田隆久,岩城孝行,渡邉裕司,竹内和彦,乾直輝,浦野哲盟,鈴木優子,井出久史,竹内譲,佐竹一夫,折坂早苗,大西明弘: ピオグリタゾン錠15mg「サワイ」およびピオグリタゾン錠30mgの健康成人における生物学的同等性試験.診療と新薬,48:291-301,2011.
  18. 松本直樹,武半優子,張本敏江,渡邉裕司,長谷川純一,竹之下(中谷)祥子,熊井俊夫,竹内和彦,小林真一: 大学病院医療情報ネットワークが運営するUMIN臨床試験登録システム(UMIN-CTR)への模擬登録体験を利用した臨床研究に関する標準化研修教材の作成臨床薬理,42:121-128, 2011.
  19. 小林真一,松本直樹,中野重行,川合眞一,渡邉裕司,長谷川純一,藤村昭夫,木村健二郎,熊井俊夫: 臨床試験を適正に行える医師養成のための教育システムの構築:日本臨床薬理学会の果たすべき役割-臨床試験を適正に行える医師の教育に関するアンケート調査(その1)-臨床薬理, 42: 5-10, 2011.
  20. 渡邉裕司: 国際共同治験を踏まえた次のステップ 治験責任医師から見た国際共同治験の現状と今後の展望.薬理と治療,39:465-466,2011.
  21. 渡邉裕司: なぜ今、早期臨床試験なのか?早期臨床試験のバイオマーカーを考える 臨床試験におけるバイオマーカーとサロゲードエンドポイント.臨床評価,39:336-339,2011.
  22. 橋本大,佐藤欄,乾直輝,豊嶋幹生,須田隆文,千田金吾: 低肺機能成人喘息患者におけるブデゾニド吸入用混濁液の治療効果に関する検討.アレルギー 免疫,18:114-118, 2011.
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